12 - 22Fred WillardMay. 19, 2007- 12 - 21Carl EdwardsMay. 05, 2007
- 12 - 20Leah ReminiApr. 21, 2007
- 12 - 19Jamie KennedyApr. 14, 2007
- 12 - 18Tom BergeronApr. 07, 2007
- 12 - 17EdgeMar. 17, 2007
- 12 - 16Rob CorddryMar. 10, 2007
- 12 - 15Episode #1215Feb. 24, 2007
- 12 - 14Lise Nova, Gwen StefaniFeb. 17, 2007
- 12 - 13Episode #1213Feb. 10, 2007
- 12 - 12Mary Lynn RajskubFeb. 03, 2007
- 12 - 11Episode #1211Jan. 20, 2007
- 12 - 10Episode #1210Jan. 06, 2007
- 12 - 9Jeff ProbstDec. 16, 2006
- 12 - 8Rocky Balboa, Mr. TDec. 09, 2006
- 12 - 7Episode #1207Nov. 25, 2006
- 12 - 6Episode #1206Nov. 18, 2006
- 12 - 5Episode #1205Nov. 11, 2006
- 12 - 4Nelly FurtadoNov. 04, 2006
- 12 - 3Episode #1203Sep. 30, 2006
- 12 - 2Howie Mandel, ChingySep. 23, 2006
- 12 - 1Episode #1201Sep. 16, 2006
The twelfth season of MADtv was broadcast from September 16, 2006, to May 19, 2007, with 22 episodes.
